Know your genetic make-up

Lab Test Diagnostics test results enable your doctor to

    • Individualize your therapy
    • Optimize the safety of your prescription regimen
    • Improve treatment compliance, especially when long-term or multi-drug therapy is required.

Adverse Drug Events

    • 100,000 Americans die due to medication-related problems every year
    • 10.7% of hospital admissions in older adults are associated with adverse drug reactions
    • While the rate of adverse drug reactions in children is lower than in adults, children with severe medical conditions are the most affected

In the Elderly

Elderly patients have decreased capacity to detoxify the drugs they are taking. Drug-to drug interactions are also an important contributor to adverse drug reactions. This makes the aging population vulnerable because of the large number of drugs they are taking.

Why Pharmacogenetics Testing?

Pharmacogenetic testing is rapidly gaining recognition as a primary driver of lowering patient costs and enhancing patient outcomes. Pharmacogenetics deals with the influence of genetic variation on drug response inpatients. Lab Test Diagnostics offers a full array of Pharmacogenetic testing panels to provide your doctor with accurate and useful results so that they can provide you with the best care possible.

Talk to your doctor to see if Pharmacogenetic testing would benefit you.

Lab Test Diagnostics is a state-of-the-art reference laboratory dedicated to providing indisputable data to the physician, enabling provider to meet their patients in an effective and timely manner. The tools available to medical providers as part of the Lab Test Diagnostics network result in an effective solution to the rising costs in our healthcare systems today.

Personalizing Medicine

Personalized Medicine is a Medical model using the molecular profiting technologies for tailoring the right therapeutic strategy for the right person at the right time, and determine the predisposition to disease at the population level and to deliver timely and stratified prevention -World Heal Organization(WHO),2013.

Genetic variation is an important determinant of drug response. The type of medication and optimum dose required for effective and safe therapy varies significantly from patient to patient. Factors that cause variation in drug responses are complex and involve genetic, environment and physiological factors.

Factors Causing Variability in Drug Responses

Genetic factors: Mutations in genes for drug-metabolizing enzymes, drug transporters and targets.
Environmental factors: Chemicals, co-administered drugs, diet, tobacco smoking & alcohol use.
Physiological factors: Age, sex, disease status.
Combined CYP2C19 and CYP2D6 will result in over 100 analyzed pharmaceutics drugs.

CYP2C19

CYP2C19 is an isoenzyme that mediates the metabolic activations and eliminations, and hence the therapeutic effects of a variety of medications.

Common Substrates of CYP2C19
Proton Pump Inhibitors Lansoprazole/Dexlansoprazole

Omeprazole/Esomeprazole

Rabeprazole, Pantoprazole

Antiepileptics S-Mephenytoin

Diazepam, Phenobarbital

Phenytoin, Primidone

Antidepressants Amitriptyline, Citalopram

Clomipramine, Moclobemide

Imipramine, Desipramine

Sertaline

Antibiotics Chloramphenicol
Antifungals Voriconazole
Anticancer Nilutamide, Cyclophosphamide

Neniposide

 

CYP2D6

Cytochrome P450 enzyme 2D6 (CYP2D6) alone is thought to be active in the enzymatic break down of 20-25% of all medicines prescribed.

CYP2D6 Substrates
Beta Blockers S-Metoprolol

Propafenone

Timolol
Antidepressants Amitriptyline

Duloxetine

Clomipramine

Parxetine

Desipramine

Venlafaxine

Imipramine

Antipsychotics Haloperidol

Riseperidone

Sertaline

Thioridazone

Aripiprazole

Antipsychotics Haloperidol

Riseperidone

Thioridazone

Aripiprazole

Anti-arrythmics Flecainide

Mexiletine

Propafenone
Opioids Codeine

Tramadol

Oxycodone
Others Dextromethorphan

Ondansetron

Tamoxifen